Suppression of Raf-1 kinase activity and MAP kinase signalling by RKIP
نویسندگان
چکیده
منابع مشابه
Molecular and Cellular Pathobiology Raf Kinase Inhibitor Protein RKIP Enhances Signaling by Glycogen Synthase Kinase-3b
Raf kinase inhibitory protein (RKIP) is a physiologic inhibitor of c-RAF kinase and nuclear factor kB signaling that represses tumor invasion andmetastasis.Glycogen synthase kinase-3b (GSK3b) suppresses tumorprogression by downregulating multiple oncogenic pathways including Wnt signaling and cyclin D1 activation. Here, we show thatRKIPbindsGSK3proteins andmaintainsGSK3bprotein levels and its a...
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Raf kinase inhibitor protein (RKIP) has been shown to be a suppressor of the mitogen-activated protein kinase pathway and is reported to be involved in human malignancy. However, the molecular mechanism of hepatitis B virus (HBV) in regulating RKIP expression is not yet clarified. In this study, we compared RKIP expression in 107 pairs of matched liver cancer and adjacent non-cancerous liver ti...
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Raf kinase inhibitory protein (RKIP) is a physiologic inhibitor of c-RAF kinase and nuclear factor κB signaling that represses tumor invasion and metastasis. Glycogen synthase kinase-3β (GSK3β) suppresses tumor progression by downregulating multiple oncogenic pathways including Wnt signaling and cyclin D1 activation. Here, we show that RKIP binds GSK3 proteins and maintains GSK3β protein levels...
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INTRODUCTION Raf-1 Kinase Inhibitor Protein (RKIP) is physiological endogenous inhibitor of the Raf-MEK-ERK pathway (1). Alterations in this pathway are associated with tumor development and progression. Recent work has shown that RKIP is diminished in some metastatic cancers. We studied lymph node negative cancers and node-positive patients, with paired lymph node metastases and show highly si...
متن کاملA divergence in the MAP kinase regulatory network defined by MEK kinase and Raf.
Mitogen-activated protein kinases (MAPKs) are rapidly phosphorylated and activated in response to various extracellular stimuli in many different cell types. Such regulation of MAPK results from sequential activation of a series of protein kinases. The kinases that phosphorylate MAPKs, the MAP kinase kinases (MEKs) are also activated by phosphorylation. MEKs are related in sequence to the yeast...
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ژورنال
عنوان ژورنال: Nature
سال: 1999
ISSN: 0028-0836,1476-4687
DOI: 10.1038/43686